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See also CARDIOVASCULAR SYSTEM. Latisse – Preparation drop. Some studies have shown that as many as 40 percent of men between the ages of 18 and 60 have some degree of gynecomastia. A man's body naturally contains a small amount of estrogen; the same mechanisms that produce testosterone also generate estrogen. Normally the balance of these two hormones in men is such that masculine secondary sexual characteristics are overwhelmingly dominant. Lower than normal testosterone levels or greater than normal sensitivity to estrogen can cause breast tissue to grow. Rarely, unilateral (one-sided) gynecomastia is a sign of breast cancer.